Anticancer activity of a thymidine quinoxaline conjugate is modulated by cytosolic thymidine pathways
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Expression of Thymidine Kinase Messenger RNA and a Related Transcript Is Modulated by Radioprotector WR10651
Previous studies have shown that the radioprotector WR1065 protects against mutagenesis across a wide concentration range (i.e., 40 MMto 4 HIM)but protects against cell killing by ionizing radiation at concentra tions greater than 1 HIM.Other work has demonstrated that many genes are induced or repressed after exposure of cells in culture to ionizing radiation, but the actual inducing agents fo...
متن کاملExpression of thymidine kinase messenger RNA and a related transcript is modulated by radioprotector WR1065.
Previous studies have shown that the radioprotector WR1065 protects against mutagenesis across a wide concentration range (i.e., 40 microM to 4 mM) but protects against cell killing by ionizing radiation at concentrations greater than 1 mM. Other work has demonstrated that many genes are induced or repressed after exposure of cells in culture to ionizing radiation, but the actual inducing agent...
متن کاملThymidine uptake, thymidine incorporation, and thymidine kinase activity in marine bacterium isolates.
One assumption made in bacterial production estimates from [3H]thymidine incorporation is that all heterotrophic bacteria can incorporate exogenous thymidine into DNA. Heterotrophic marine bacterium isolates from Tampa Bay, Fla., Chesapeake Bay, Md., and a coral surface microlayer were examined for thymidine uptake (transport), thymidine incorporation, the presence of thymidine kinase genes, an...
متن کاملFeedback Inhibition of Thymidine Kinase by Thymidine T&phosphate*
That the regulation of cell division and deoxyribonucleic acid synthesis is subject to some kind of chemical control in higher organisms is widely accepted (2-5). Davidson (2) has suggested that deoxyribonucleic acid synthesis takes place at critical concentrations of the deoxyribonucleoside triphosphates and that these compounds are components of a homeostatic mechanism. There are now at least...
متن کاملFeedback Inhibition of Thymidine Kinase by Thymidine Triphosphate.
That the regulation of cell division and deoxyribonucleic acid synthesis is subject to some kind of chemical control in higher organisms is widely accepted (2-5). Davidson (2) has suggested that deoxyribonucleic acid synthesis takes place at critical concentrations of the deoxyribonucleoside triphosphates and that these compounds are components of a homeostatic mechanism. There are now at least...
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ژورنال
عنوان ژورنال: BMC Cancer
سال: 2015
ISSN: 1471-2407
DOI: 10.1186/s12885-015-1149-5